Endotoxins waa unugyo yar yar oo bakteeriya ka soo jeeda hydrophobic lipopolysaccharides (LPS) oo ku yaal xuubka unugga ee bakteeriyada garaam-negative.Endotoxins waxay ka kooban yihiin silsilad polysaccharide xudun ah, O-specific polysaccharide silsiladaha (O-antigen) iyo magdhow dufan, Lipid A, kaas oo mas'uul ka ah saamaynta sunta ah.Bakteeriyadu waxay ku daadisaa endotoxin xaddi badan markay dhimato unugyada iyo marka ay si firfircoon u korayaan oo u qaybsanayaan.Hal Escherichia coli ayaa ka kooban qiyaastii 2 milyan oo unugyo LPS unug kasta.
Endotoxin waxay si fudud u wasakhayn kartaa shaybaadhka, joogitaankiisuna wuxuu si weyn u qaybin karaa tijaabooyinka gudaha iyo vivo labadaba.Iyo alaabooyinka parenteral, alaabada parenteral ee ku wasakhaysan endotoxins oo ay ku jiraan LPS waxay u horseedi kartaa koritaanka qandho, kicinta jawaab-celinta bararka, shoogga, xubinta taranka iyo dhimashada aadanaha.Alaabta sifaynta, LPS waxa lagu wareejin karaa xuub leh xajmi weyn oo dalool ah iyada oo dib-u-shaandhaynta dheecaanka sifaynta dhiiga, dhibaatooyinka bararka ayaa laga yaabaa inay sababto.
Endotoxin waxaa lagu ogaadaa Lyophilized Amebocyte Lysate (TAL).Bioendo waxay u heellan tahay cilmi-baarista, horumarinta iyo soo saarista TAL reagent in ka badan afartan sano.Badeecadahayadu waxay daboolayaan dhammaan farsamooyinka loo isticmaalo in lagu ogaado endotoxin, kuwaas oo ah farsamada gel-xinjirowga, farsamada turbidimetric, iyo farsamada chromogenic.
Waqtiga boostada: Jan-29-2019
